Sure, but that's only if you actually trust the non-profits in question to do actual good with unrestricted grants. Consider the example of the UNH librarian who ate frozen dinners and vending machine burritos for decades and donated his life savings to the school, only for the school to squander it on a scoreboard for their terrible football team:

https://deadspin.com/how-unh-turned-a-quiet-benefactor-into-...