I grew up and live in Indianapolis. It's only happened a handful of times, but while visiting San Francisco someone would say, "I'm sorry," after hearing that I live in a "flyover state." Of course, these folks weren't from San Francisco either. (I think I've only met one or two actual natives of San Francisco.) This has also happened in New York City.
I don't mean to tarnish the people of San Francisco, though, because I love visiting SF and the people there are the nicest I've ever met, anywhere.
I also understand that people want to preserve what good they have going on there, though, but I often wonder if this is because they're thinking about the greater good; or, some other self-satisfying motive.