MDMA and cannabis are both quite popular and talked about openly but I think that's more a general reflection of the culture in places like NYC and the Bay Area, where I have personal experience.
Good luck with the book by the way. One word of warning: please try very hard to avoid falling into a simplistic narrative that will contribute to drug prohibition. Criminalization of drugs has, IMO, ruined far more lives than drugs themselves. A former Columbia colleague, Carl Hart, professor in the psych department, has written a lot on this and might be worthwhile as an interview subject for your book. Personally I think he sometimes pushes too far in the opposite direction, but he is nevertheless an important public voice speaking up against decades of scaremongering.