I'm in tech. My first experience with drugs other than weed, which I just don't enjoy, happened relatively late. I was around 30 at the time when I joined friends of a friend taking MDMA at a club.
I have experienced chronic depression for as long as I can remember. I was rarely actually "sad", as one might think. I was simply experiencing most emotions through a sort of fog. The most troubling symptom has always been what one would just call "extreme laziness". Even though I frequently attempted all sorts of methods to motivate myself and acquire discipline, I always failed. Recently, I found a "contract" I made with myself when I must have been around 12 years old, specifying all sorts of activities such as sports, reading, and socialising to be completed on a schedule for certain rewards. Later, I sought help through the medical system. But even though I tried three different anti-depressants and two therapists, their valiant efforts failed to make a dent.
After three years of recreational drugs I cannot say that they are the answer to my problem. But it is certainly an experience that has helped me make some inroads. Much like learning to bike with training wheels, they gave me an appreciation of the range of emotions one can experience. Both exhilarating, all-forgetting thrill, as well as content serenity, were states I only knew from literature.
I've consumed MDMA, 2CB, LSD, Speed, and Ketamine. I'm staying away from Cocaine, all opiates, and GHB. I do consume speed at work. The enjoyment of working in a flow-like state is magnificent, although it comes with its own downsides, mostly a tendency to dive into time-wasting side-issues. Even though I have overdone it on multiple occasions, sometimes working for four days straight, I've have never had trouble not taking anything for a few weeks when I was travelling, or simply ran out. I've also almost completely stopped drinking alcohol.
I've been in a joyful relationship for the last five years, and we've used drugs to find previously unthought-of depts of sexual pleasure.