"It depends"

As someone who has gone through this for some 20 yrs, it's usually a faster commute to travel from Hoboken to pretty much anywhere along/south of the PATH line during peak hours (so 34th down to the southern tip of Manhattan) versus a starting point of the UES/UWS (which is where the comparable housing exists).

My commute from Hoboken to various startup locations in NYC was consistently ~45 minutes door to door, versus an hour for my friends on the UES/UWS.