Maybe in the Navi generation? It would make for a very pretty lineup to have, say, Navi 10 / 14 / 24 be APUs, Navi 36 / 44 be a budget discrete GPU pair, have Navi 56 / 64 be shrunk Vega cards, and then some high end 2080 Ti competitor series of new cards called Navi 80 / 88[1]. If they can get power under control and have the TDPs like up like 45 / 65 / 95 / 120 / 150 / 170 / 200 / 210 / 250 watts they could have a really viable lineup no matter what Nvidia pulls...
[1] Having a GPU called the 88 would just be marketing bliss. "When we get this thing up to 88 compute units you are going to see some serious shit".