Completely anecdotal but i saw friends who moved on to long term use of "skunk" in the UK change a lot. They never kept up with the pack or reached close to their potential and ended up drifting away from the friendship group.
I can only speak for a sample size of 3 people out of 40.
Correlate all you like, but if it's causative, then I need to disappear in a puff of logic.
Sounds like you have a one-dimensional view of change and potential.