That's a niche site, how could you broaden it out, though?
Another interesting idea, would be for submitters to authenticate with such a site, and have it check their "retweets_of_me" "retweeted_by_me" and "retweeted_to_me" aiming to surface what's important.
Tweetmeme has a comedy channel, I wonder how they get their tweets. http://tweetmeme.com/category/comedy - but the tweet is not initially shown, only the link and its extracted content.
Is there a twitter site aimed at crafting the best possible lists in certain categories?