I ran NT4 on a MIPS Magnum R4000 for a while. It worked okay. Could run 16bit x86 Windows/DOS stuff in a weird sort of translation/emulation.
All my Multias (I owned 2-3 over the years) usually ended up with RHEL on them; nobody in the nerd crowd I was in wanted to run Windows on them. They ran so hot that if you sat it horizontal it would keep your coffee cup warm if close enough.
I believe someone got VMS running on one after some hackery with the firmware/BIOS.