In a lot of SEA and EMEA markets road signs, signals, traffic lights, etc. are often non-existent, wrong or broken. Intersections may have 10-20 signs all oriented in a non-standard position.

Throw in motorists and bicyclists that are constantly swerving between lanes and inches from cars. Seeing current videos of how self-driving cars react, it would constantly be jerking in different directions.

There are also lots of local habits that self-driving cars would need to be trained to do, eg in Nepal when in a two lane and you spot an oncoming car, you turn on your right blinker to signal you see each other and can pass safely.