There's a factor of 10-40x speedup by going from an interpreted language like Python/Ruby/PHP to a tight compiled one like C++/Rust/Ocaml. 2-4x going from a good JIT like V8 or Hotspot (or Go's runtime, though technically not a JIT). Probably another 10-100x by cutting out bloated middleware like most web frameworks or the contents of your node_modules.
All this was irrelevant when you could get your 2-4x speedup by waiting 18 months, and your 10x speedup by waiting 5 years. It's very relevant when your 2x now takes 20 years and 10x takes a lifetime. Maybe this is why Rust gets so much attention recently.