I have an old version of Myst IV and Myst III, and they run just fine on my windows 10 installation. Totally thrilled by this project though :) The series (and especially Riven) kept me in front of the computer for a loooong time in my youth.
The one that gave me the most troubles was Riven (before I got it from GOG). For this one I had to do some mumbo-jumbo to finally get a full screen yeah.
I gave up on CDs when I was dealing with a corrupt CD drive or SATA cable.
It was weird, but after I disconnected it, it took me years to use it, and that was for Ubuntu install.