Does the rocket equation still bite to hard if fuel production is outside Earth's gravity well?
We really need to be able to get places in a couple of weeks, and chemical rocketry just gets absurd for that; even if you can do it, you've got to fling massive refueling stations around and such. A fusion-based system would have power density sufficient to not just fly to Mars in a reasonable period of time, but to fly back without having to be refueled, which means we can go places without first figuring out how to build a fairly expensive and massive infrastructure that allows us to get back.