What I'd like to know is if the "irreproducibility crisis" is really some combination of "sample size was too small" and "effect size was too small". When I went through a lot of these studies myself and saw the ones that don't reproduce, I saw this theme over and over. "P-hacking" is less of a concern to me when the effect is real and widespread.

It's so bad now that for any article/study, I look at the sample size first. If it's too small (especially < 100) or they don't say I just ignore it. And if you don't publish or give some estimate of your effect size I just think about it directionally but don't give it much weight mentally.