This would be amazing. If it could handle >= 32GB of RAM and 2 SSDs and run two 4K monitors at once, this would be so amazing and replace most of our desktops.
By breaking Intel's hold on the NUC form factor, it should bring prices down as well.
[1] https://forums.anandtech.com/threads/amd-ama-starts-at-12pm-...
edit: As AMD is already throttling DRAM speed dynamically for Ryzen Mobile to conserve power, it would be an interesting experiment to see if they could throttle ECC DRAM even lower, so that it consumes less power than normal DRAM.