I have never, ever met a psychonaut that doesn't advocate "set and setting".
Set and setting is important. Do not try psychedelics to solve problems.
But set and setting is not everyting. A bad trip might happen anyway.
Who knows about its genetic, biological and psychological constitution and reaction before the trip ?
That is why a medical expert as trip sitter is so important.
"Despite these difficulties, it is notable that 84% of respondents reported having benefited from the experience, with 76% reporting increased well-being or life satisfaction attributed to the experience."
Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551678/