Sure, I tried it over Shopify because I wanted the ability to have complex pricing (well over 100 per product). I built a system that allowed for the ability to have dynamic prices based on the base product price + a combination of selected options.

Craft has a fairly sane way to do plugins. Commerce itself is a well written if sometimes obtuse plugin, which is handy because some of the documentation isn't great (the new version - 3 - looks better). It is an EVA database, but it's simple to navigate and debug. There's some fairly powerful ways to handle loading content.

In summary I'd say have a poke around the commerce plugin, you can run it for free unlicensed. It has a growing ecosystem of plugins, which is nice coming from Spree. Oh and support is pretty good too.