Also, do you use preventative measures like ergonomic keyboards and mice?
Within the first year I experienced prominent wrist pain, primarily in the mouse hand. I had to deal with many applications across three 1920x1200 monitors.
Things that helped:
> I used a Wacom Bamboo tablet for several months to completely replace the mouse. I became pretty skilled at using it and it helped a lot with the RSI. It was a good experience and it's nice hardware for the cost, too.
> I bought a pair of wrist braces from Amazon. I used them while working and while sleeping. They provided excellent pain relief by keeping my wrists fixed and stable.
> A mechanical keyboard. I've bought and used several, but an old Das Keyboard with MX brown switches remains my favorite and most comfortable keyboard. I'm sure an ergonomic variety would be even better but I'm comfortable with the standard QWERTY.
> I gradually increased my mouse sensitivity. This was one of the most important changes, as my hand no longer needed to travel as far to accomplish the same tasks. My window configuration was already pretty optimal for me.
My RSI resolved within a year or so. I stopped using the braces and Wacom tablet but keep them on hand just in case.
I haven't had any problems since.