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I'm a Python programmer, so what I'm most interested in are Python and PyPy. Both with ctypes and with the cffi module.

Here looks like a GitHub gist you could use to do it for cffi vs Cython in Python, and PyPy.

Thanks! Yes, it does.

ctypes is pretty slow in my experience. Cython is a nice alternative. Native speed and datatypes where you need them, plain old python anywhere else.

Yes, my experience with CPython is that ctypes is slower than writing (or generating, as is the case with Cython) the Python/C extension.

However, one advantage with ctypes is that it can work with other Python implementations, like PyPy.