Do you have strong opinions about abortion? Whatever they are, there's a non-profit actively working to the contrary.

Do you have strong opinions about what is a bad way to help poor people, perhaps even harming them? There's a non-profit doing that.

Do you have strong political opinions? There's a non-profit, probably a very well-funded non-profit, promoting the opposite with things you consider lies.

That's before we even get into corruption or just plain administrative competence. Specific examples would just set the thread aflame; it's pretty obvious "hideously ineffective" and "[what] I find full-stop evil" non-profits exist. Your list may be different than my list, but we could both come up with one. Unless you have no strong opinions, in which case we could probably still find something in the political category to get you worked up if we tried.