On the front end, I tend to lean towards abstractions that work together... I really like React and the material-ui library's switch to JSS. It's relatively clean, and useful. Even then, it's only a mild syntax adjustment, not a full on abstraction. React is more of an abstraction, but that comes with functional paradigms that aid in testing, and predictive behaviors.
It really depends though. One can always do just JS/HTML/CSS, and there's something to be said for that. There are lighter tools that are similar to JQuery to smooth over a few of the rough edges. There's really an ala cart of available options.
The problem is that people assume that the PFM (pure fucking magic) will solve it all for them. You can use the cleanest or simplest abstractions, and then still write layers of incomprehensible spaghetti in between.