Looks nice overall. But Caslon is a bit blurry and hard to read at less than 18px on Windows with Cleartype enabled. I'd either switch to Georgia or bump up the size.
An aside, but one thing I love that both Safari and Chrome now do (at least, maybe others do as well) is remember the font size instructions for a site. So, if you bump up the font size -- next time you visit it keeps it at the larger font size.