The A380 was doomed from the start. It was built to compete with the 747, a jet which first flew in 1969 [1] and designed for hub-and-spoke "trunk" routes. In that narrow aim, the A380 succeeded. The problem is the entire A380/747 category peaked before the A380's first flight. High-efficiency engines mean long-and-skinny routes are now profitable. Instead of packing Chicago to London and D.C. to London passengers into a JFK-Heathrow megaflight, one runs Chicago-Heathrow and D.C.-Heathrow with medium jets.
At the end of the day, the A380 was designed to be impressive to European politicians more than to airline executives.