It's a little embarassing to admit on YC news ;), but pretty much all of the code I've ever written was Visual Basic interfacing with Microsoft Excel!
As a scientist, most data from most instruments gets spit out into Excel files. Being able to interface between Excel and VB allowed for powerful data processing. (My advisor built an entire CO2 climate model in Excel a few years ago!) I'm sure it was all much slower than it would have been written in another language, but it was easy to look at and it did the trick.
What am I supposed to do now? Teach myself Matlab? Not upgrade Excel?