I'd say San Francisco is in, at least, their 3rd decade of being a toxic career home. Moved there in '93 and left within 9 months, as every tech company was abusive and managed by alpha personality, politically motivated yet drifting nincompoops. I was an OS developer for the unreleased 3DO, in the midst of high competition for developers like myself. The atmosphere in SF was so out of control, I went to Japan and Sony for some order.