GMail now finally works with Yubikeys! Switching from Chrome is now finally possible.
How about Duo secured sites?
I ported u2f-hid-rs (the library Firefox uses) to FreeBSD, it's been in the www/firefox port for a while and now accepted into mozilla-central I think.
The Chromium FreeBSD port also has had U2F support for a while.
I'll have to try it the next time I update