The thing is, we don't know where this line of reasoning would even lead. I mean, people used to think that light had to travel in little packets through luminiferous aether [1] and look where that investigation led: Einstein, special relativity, atomic weapons and power, nuclear medicine, etc.
Let's say the universe is fundamentally indistinguishable from a computer simulation. What consequences does that have? What does that say about the types of math that can be used to describe the universe? Or, perhaps better, the types of math that shouldn't be used to describe the universe? What does that say about our ability to model a portion of the universe and therefore predict outcomes? Does it have implications for stochastic processes? Indeed, where is the stochasticism coming from? Is everything predictable or is there some fundamental randomness?
On the other hand, what if we can show that the universe is distinguishable from a computer simulation. What does that mean for our understanding of the universe as it exists? Does it reveal a fundamental aspect of reality that we have missed, or a limitation of our mathematics, or a fault in our computer models or design, etc.? We're dogs learning calculus here, and the universe isn't obligated to make sense.
Even if we can never find a useful test for this hypothesis, the line of thinking itself potentially leads us into new areas of discovery.
[0]: https://gizmodo.com/5950832/how-to-tell-if-the-universe-is-a...