* How many habitable planets are out there? We're just now starting to get data on this, there might be a lot
* Of those, how many develop life?
* Of those that develop life, how many develop intelligent life?
* Of those that develop intelligent life, how many advance to the point where they're capable of interstellar travel? How many are interested in interstellar travel?
* What if FTL travel is simply not possible? STL interstellar travel could basically be a one-way trip. Maybe most (or all) alien civilizations are unwilling to explore beyond a few light years.
* What is the lifetime of a space faring civilization? maybe all the alien civilizations just died out before they explored very far.