Chronic CB1 receptor antagonism is associated with:
- lowered blood pressure
- increased levels of Akkermensia bacteria in the gut (associated with leanness)
- decreased lipogenesis (creation of new fat cells)
- decreased fat masss
- resistance to obesity, despite caloric surplus
- increased fatty acid oxidation
- increased adiponectin
- increased transdifferentiation of white fat into metabolically active brown fat
- increased insulin sensitivity
- reduced insulin levels
- increased leptin sensitivity
- reduced proteinurea and improved creatinine clearance in kidney disease
- smoking and cocaine cessation
- reduction in depression symptoms
- reduced anxiety
Search PubMed for "CB1 antagonist" or "chronic CB1 blockade" to see what kinds of things CB1 antagonism can do. You'll find quite a lot of research into Rimonabant (another CB1 antagonist) but unfortunately it was found to cause psychological side effects like depression and suicidal ideation; CBD does not have these effects.
There are several anecdotal reports the on /r/cbd subreddit where people start taking it for anxiety and depression, and end up losing 10-40 lbs. of excess weight without trying.
I've found that it helps me sleep deeply, helps me focus at work, and I am satiated after much smaller amounts of food than before. I also notice that I can run at a significantly higher intensity on the treadmill for much longer with CBD.
I have recommended CBD to 7 or 8 people, and each one reports a plethora of benefits: helps depression, anxiety, ADHD, sleep, weight loss, brain fog, overeating, etc.
There seems to be a good amount of variety in the quality of non-isolate CBD products. Some contain minute amounts of THC and other psychoactive cannabinoids, so they may cause you to fail a drug test if that's a concern.
CBD is one incredibly beneficial compound. I highly recommend you try it if it's available where you live.