OK, so alcohol-based sanitizer isn't great. How does it compare to plain old soap and water? What about foaming liquid soap? How does the big gun of Hibiclens work out nowadays?
OK, so alcohol-based sanitizer isn't great. How does it compare to plain old soap and water? What about foaming liquid soap? How does the big gun of Hibiclens work out nowadays?
And out of which bacteria membranes are made.
We know these organisms adapt, just as they did to (oral) antibiotics. Is there any biological reason why hand sanitizers would be any different?
The mechanism of action for hand sanitizers is to disrupt the lipid membrane - it's possible no adaptation exists to make a lipid membrane resistance to high concentrations of alcohol (or other surfactants) that also still renders it a workable membrane.
The current resistance mechanisms in the study are mostly efflux pumps, which again, may not be expressible to save a bacteria when alcohol is present at volume. Even most antibiotic resistance mechanisms are not actually a binary "Works/Doesn't Work" but rather can fight off the antibiotics at the concentration they're delivered in.