The trans community. A lot of us are nerdy as hell and we're consummate biohackers who can tell you shit about your endocrine system that will astonish.
There's a meta-hack, of sorts, however, that is:
"You don't have to be this way, and you don't have to do what others expect of you. You can change, and you don't have to ask permission. They will make you pay for it -- your friends, spouses, colleagues, institutions -- but the cost of the alternative can be higher still. Be free."