I think it's important to think about the trends and averages in the broader society before levying accusations of sexism. If a bank's male customers have higher average account balances than the average woman that holds an account, is it fair to call the bank sexist? If a publishing company hires mostly female publishers is it a sexist company? I'd argue no in both cases. In both scenarios the disparate outcome likely stems from broader trends in society - higher incomes among men, higher readership among women. It's entirely possible and definitely worth discussing whether these trends are influenced by sexism - but that very different than calling our hypothetical bank or publishing company. An organization or process is sexist if it exerts unequal treatment on the basis of gender. It's entirely possible for a completely unbiased process to create an outcome with gender disparities.

This American Life isn't one of the primary NPR podcasts to which I listen, but if it follows the trend of other NPR podcasts it probably draws more heavily on subject matter experts (e.g. university professors) and leadership positions in private enterprises than the rest of the population. These occupations, at least the latter, are disproportionately occupied by men. One could argue that the bias towards subject matter experts is sexist, but that seems fairly weak and indirect unless it can be demonstrated that the choice of interviewing these people is motivated by a desire to interview more men than women. One could also argue that the podcast should stop its focus on subject matter experts - but that would fundamentally change the nature of the podcast, essentially making it a different product.