This is why I believe that qwerty is the best layout. All applications have designed all shortcuts to be sensible on it. Any other layout is just going to be a disaster and negate any benefits and more during actual use.

You can of course use whatever layout you like and then while ctrl/alt/meta is pressed it switches to qwerty, doesn't save vim users though (or other applications where shortcuts don't need to be prefixed).

I'm not convinced switching from qwerty is that beneficial, I believe (but have not yet tried it) an orthogonal keyboard will do more than any layout will. But I admit that I don't have experience to back that up.