If your concern are licensing the patents, MonoMac only uses the ECMA core and the MS-PL bits. If you want to use stuff outside of this and you are still scared of Microsoft going after your very profitable enterprise, remember that Microsoft is open to licensing their patent portfolio to anyone that wants it.
If Mono were to be discontinued, there is a business right there for an enterpreneur: negotiate with Microsoft a license deal for their patents, add a markup, pocket the difference.
That is the worst case scenario, you have to pay the patent holders.
That being said, you do live in a dark, sad and terrifying place. You harvest what you plant, and this fear and horror that you plant can not be good for anyone's health.