How do you fairly determine salaries for remote workers? Does it take into account their location? Also, does it account for the fact that SV workers (if they can afford a house) may be able to net six-figure appreciation (at least during certain periods)?

The 3x runway outside SV is undoubtedly true, but I wonder how VCs feel about that. My understanding is that VCs typically want to give you no more than 18-24 months of runway. Are they cool with startups raising money and then enjoying a 4-6 year runway with remote workers?