I’ve made a few attempts to do this (often with org-mode, pdf-tools, and interleave-mode), but I’ve always gone back to printing and scribbling on paper. It just feels more natural, but my notes end up being more ephemeral.
I’d like to be able to sync and search my notes very much, however! Any tips?
Reading with a desktop or laptop has been easier for me since it's more familiar. I'm not really a fan of mobile phones or kindle readers. Evince or fbreader work OK on linux. You could add espeak or another TTS tool for speaking text. On OSX there's acrobat with voice over. Screen readers exist but are harder to control. The tools for reading via TTS are pretty primitive right now unfortunately.
I'm pretty bad at syncing notes... I've primarily done it with rsync over ssh. If you save things back to a server and sync from there that could work. Otherwise there's easier stuff like Google Drive or Dropbox.