I think everyone could benefit from suggestions.
To start things off, I'm a big fan of WNYC's Radiolab podcast. Every one I've heard has been fascinating, and well-produced.
I can understand wanting higher quality entertainment than South Park, but don't fool yourself into thinking an NPR podcast is a better use of time if it is likewise distracting you from things you need to do.
Be sure to checkout Stanford's Entrepreneurship section! Also, research channel (also on iTunes) exposes some incredible academia work - kids, this is a great place for your idea hunting on the next big thing (why read when you can watch them present?)
this american life
security now
TWIT
TWIS
the sound of young america
jordan jesse go
never not funny
car talk
they're all a little more entertainment-centric, but i like to split my mind like that when working.