Can you hold securely in one hand and pull down Control Center from the top right corner with your thumb? It's one of my most commonly used features and when I tried one in the store it was impossible for me. (EDIT - try this left handed, it's even worse)
Walk outside
Glance at my phone
Want to turn the brightness up because the sun's out
Set down whatever I'm carrying in my other hand
Turn up the screen brightness
is not how I want to use my phone. I guess you get used to not being able to do that, or you get one of those adhesive grip nubs on the back of it, but "Can not be used effectively one handed" is basically my threshold for whether a phone is large or not.
I guess the workaround for this is
Homescreen
Launch Settings app
Display & Brightness
Increase slider
Change back to the app you were using
Works, but that sounds like a huge nuisance.