While the fight against it is rather dire and no end will ever be in sight, I'll nonetheless never stop (tool assisted) fighting.
Anyway, @zoho.com addresses used by spammers started to pop up circa a month ago and increased rapidly in occurrence. As we use stopforumspam to report and track spammer info (and surely are not the single forum seeing those @zoho.com domains) you may got a few flags raised somewhere.
Not sure what caused this sudden (from our POV) attraction of spammers using zoho, you may want to look into some defense against this. While a full solution may not be achievable it's often enough to be faster than other providers, aka the tiger defense ;-)