* I am not a fan of asyncio's API (`ensure_future`), docs (though I understand these two are improving in 3.8) and of the fact that it is incompatible[1] with much of the existing ecosystem of libraries (eg. the SQLAlchemy ORM or any existing libraries that talk to... anything over the network (postgres, redis, memcached, etc.) which need to be written from the ground up in asyncio style or rewritten so their protocol parsing logic is completely separate from the IO that they do (not a bad thing, mind you, but taking battle-tested libraries and rewriting them from the ground up is not the greatest idea)), tools and even builtins (queue.Queue vs asyncio.Queue).
* I don't buy into the claimed benefits of explicitly marking yield points: any sufficiently complex code will have enough yield points (`async with`, `async for`, `await`) that reasoning about concurrency in the program isn't going to be any easier than if it had implicit yield points.
* I think ergonomics matter for developer happiness and programming with asyncio is not ergonomic in the slightest.
* File IO is blocking.
Put all of those together and you end up with a system where you can't use any of the popular, battle-tested, libraries out there, where your code is more verbose for minimal gain and where seemingly benign things (reading a file, using a `for` instead of an `async for`) may greatly impact the performance of your program all for a small increase in throughput (assuming it does increase!).
[1]: http://journal.stuffwithstuff.com/2015/02/01/what-color-is-y...