I’ve printed a good number of images shot on m43 at about that size, and that’s not been my experience. The specifics definitely matter, but I’ve found Olympus’s M.Zuiko 75/1.8 to be competitive with a 70-200/2.8 in terms of sharpness, distortion, etc, for instance (dxomark seem to broadly agree: https://www.dxomark.com/Lenses/Olympus/Olympus-MZUIKO-DIGITA... vs https://www.dxomark.com/Lenses/Nikon/AF-S-VR-Zoom-Nikkor-70-...). You do have a larger minimum DoF, but 150/3.6 equivalent is not that far off.
I would like a bit more resolution, but that’s also true of my Nikon D4S (also 16MP).
Clearly FF and m43 have different strengths, and you’ll get the best results by playing to the strengths of each. I concede that all else being equal, larger sensors do afford you more flexibility (lower light performance, for instance). On the other hand, traveling with my Nikon FF kit is a huge PITA (mostly due to the lenses; the body is a constant cost I can mostly deal with).
I’d love to hear more about the limitations you’ve hit with larger prints on m43.