This is more or less simply impossible. If we observe some fact X about our universe we have no source of truth that can tell us whether X should be true or false for real universes, simulated universes, or both kinds of universes.
It is an attempt to distinguish something we don't know from something else we don't know. Everything we know about our universe might be something that applies to real universes or something that applies to simulated universes depending on whether we live in a real universe or in a simulated universe. Even worse, we know nothing at all about simulated universes if we live in a real universe and we know nothing at all about real universes if we live in a simulated universe.