Again, the Mochizuiki situation is quite different. You're really not understanding these things if you think they're comparable. Mochizuiki's work is legitimate and real and serious. Whether or not it is correct is difficult to ascertain, because of its genuine complexity.
The accusation being made here is that these fields are incapable of separating absolute nonsense from genuine content. Which means that their work is indistinguishable from nonsense and absurdity. The work that Ioannidis did demonstrates that people acting within a good framework are producing work with a higher error rate than you might expect given the claims they make. That work is extremely important. But it doesn't invalidate the field of economics, or medicine. This work attempts to invalidate the entire edifice that these disciplines are built upon. It is extremely different and not comparable at all.