The obvious difference is transactions without a third party. You can also verify ICO token integrity on the blockchain yourself (via open source apps).
Anybody who's more worried by the potential complications of T+2 settlement when purchasing blue chip stocks than the Wild West world of ICOs shouldn't be investing.
Maybe it's less about trust and more about permission. With token based securities I could trade with whomever I choose whenever I want.
Interesting to see how it turns out in the end.