To counter lots of (possibly unfounded because too general and/or lack of actual experience) negativity here: the problems will mainly depend on the co-founders. Non-technical doesn't per se mean completely ignorant or stupid. If they are reasonable and smart, they recognize you are the one who knows the tech stuff and hence will let you take care of the technical side without much questions, let you experiment and go your own way, will value your input when it comes to decision-making on the software front, won't set insane deadlines, ...
Such people exist, I've worked with them, and that was all good. In the beginning it did sometimes take lengthy discussion why some features couldn't 'just' be implemnted but for the rest the main problem I had was getting into a 'me alone on an island and I'm the king' state leading to less self-critique and being stuck with old tools while better stuff is available. But nothing that cannot be fixed by keeping an open mind and reading around on the internet on the tech used.
Obviously if your co-founders don't quite fall in this category, yeah, running might still be the better option.