Is there any description of the actual interventions?
Could this be useful even for healthy people as a way to boost cognitive performance and prevent dementia later in life?
Could this be useful even for healthy people as a way to boost cognitive performance and prevent dementia later in life?
"Increase telomere length" - is that even doable at the moment?
"Increase GABA" - I thought oral GABA supplements do not cross the blood-brain barrier?
Others sure are doable:
"Enhance leptin sensitivity" and "Increase autophagy" can be done AFAIK by intermittent fasting (even better, water fasting several days).
"Enhance mitochondnal function and biogenesis" - any kind of sports, CoQ10 and photobiomodulation come to mind (BTW I've heard of a pilot study where they greatly improved Alzheimer's for ~2 weeks after a treatment with a near-infrared radiation helmet).
"Reduce homocysteine" - supplement B12 (ideally, methylcobalamin).
Most of the mentioned hormones (upper half of right column) can be optimized with medication.
"Reduce inflammation" is likely very beneficial, but tricky; eliminate all foods that cause autoimmune reactions?
Oral GABA doesn't cross the BBB in appreciable concentrations, but I assume they mean increase GABA neurotransmission, which can be done with any number of ligands that do cross into the brain. Probably not benzos, since long-term usage increases the risk of Alzheimer's (and cognitive impairment is an effect even in healthy individuals). But perhaps something like baclofen (chloro-phenyl-GABA) which was tested in a rat model here: https://www.ncbi.nlm.nih.gov/pubmed/29133125