For example, learning React itself is great because you can pretty quickly see how it cleans up your UI layer. It doesn't take that long and adds real value to your projects.
Oh, but now you need to learn all the corner-cases of NPM, and now you need a new test framework, and now you need to figure out the incantations to get webpack x.y.z outputting just the right way. Oops now hot-reloading is broken. And the chrome inspector is lagging for some reason.
None of these are interesting or fun problems to solve, but they are a pretty substantial part of getting any new technology into production.