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I'd rather say: In that very moment, aim for something that you really love doing. That might change over time, but don't ever pursue something for the wrong reasons (e.g. get rich quick & retire in your 30s). It will just eat you up.

Randy specifically argues that you should not be motivated by money alone, but rather by the passion of solving a problem, improving someone's live, etc.

The key is "Rest of your life" might be 5 years. You don't know. The next 5 years is every bit as important as the next 50. Looking back 50 years from now, regardless the outcome, will you be proud about what you're currently doing? It sounds like you already know a few things you'll be proud of trying which is a good start, just make sure they're prioritized in the order that matters most to you.

Read the post and you'll understand the question in a different light, why it's hugely relevant even to tech-founders...and who really asked it.