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I wonder if we can have a pill to maintain high level of mitochondria in all our cells in background.

It seems that modern humans have a lot of power-saving traits which are active deterrent as of now when food is abundant, since they lead to obesity, muscle loss and mitochondria problems here. Other mammals don't seem to have such problems en masse.

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Co-Q10 definitely helps keep mitochondria healthy, fasting should also help. Also, avoid certain antibiotics that are known to damage them (mitochondria evolved from bacteria, so that‘s not too surprising). Avoid overtraining and stress in general, as they are very susceptible to oxidative stress.

Our bodies evolved to be a lot more active than the average person today. I would be surprised if it's the only thing that exercise helps and as such I would be skeptical about how beneficial a pill would be.

Well, too bad, we need to find ways to change those settings.

Exercise can be pretty enjoyable if you find a way that suits you. Personally I can't stand the monotony of the gym, but I love mountain biking or white water kayaking. The later has benefited me in my life so much - it has taken me to amazing countries that I doubt I would have visited otherwise and I have made some amazing people through the sport. There is no way that a pill could compete with that.

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