If you are interested, there’s lots of computational work to do in chemistry and applications. It might be hard to break into without going to graduate school, but there are many free high quality software available.

For chemistry with localized molecules, a potential software to look up might be Orca.

For physics and bulk materials, I am a fan of Quantum Espresso.

You probably won’t discover a new drug (whether you do computation or experiments), but computation can give an understanding about how existing drugs work and/or how they can be synthesized.